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Despite their differences, the two systems allow comparison for statistical purposes.

Pre-exposure prophylaxis (Pr EP) with a daily dose of the medications tenofovir, with or without emtricitabine, is effective in a number of groups including men who have sex with men, couples where one is HIV positive, and young heterosexuals in Africa.

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During primary infection, the level of HIV may reach several million virus particles per milliliter of blood. This weakens the immune system and allows opportunistic infections.

T cells are essential to the immune response and without them, the body cannot fight infections or kill cancerous cells.

It is also linked to the breakdown of the immune surveillance system of the gastrointestinal mucosal barrier caused by the depletion of mucosal CD4 The CDC's classification system is more frequently adopted in developed countries.

Since the WHO's staging system does not require laboratory tests, it is suited to the resource-restricted conditions encountered in developing countries, where it can also be used to help guide clinical management.

and is frequently associated with adverse effects—where zidovudine is used, about 70% of cases result in adverse effects such as nausea (24%), fatigue (22%), emotional distress (13%) and headaches (9%).